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KMID : 0043320070300030313
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Archives of Pharmacal Research
2007 Volume.30 No. 3 p.313 ~ p.316
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Topoisomerase I Inhibition and Cytotoxicity of Licochalcones A and E from Glycyrrhiza inflata
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Yoon Goo
Kang Bok-Yun
Cheon Seung-Hoon
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Abstract
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Licochalcones A (1) and E (2), retrochalcones or reversely constructed chalcones, isolated from the roots of Glycyrrhiza inflata, were evaluated for their cytotoxicities against four different human tumor cell lines; A549 (lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma) and HCT- 15 (colon), using the sulforhodamine B (SRB) assay. The effects of these compounds toward the DNA topoisomerase I (topo I) inhibitory activity were also measured using the supercoiled DNA unwinding assay. All compounds showed moderate cytotoxicities against the four different human tumor cell lines and inhibited the topo I activity in dose-dependent manners. The inhibition of topo I by licochalcones A (1) and E (2) may explain the cytotoxicities of these compounds against the human tumor cell lines.
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KEYWORD
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Glycyrrhiza inflata, Licochalcone A, Licochalcone E, Cytotoxicity, DNA Topoisomerase I
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